Donor site complications of buccal mucosa harvesting in substitution urethroplasty

Authors

DOI:

https://doi.org/10.59736/IJP.24.02.1078

Keywords:

Buccal Mucosa, Mouth Diseases, Postoperative Complications, Urethroplasty

Abstract

Background: Buccal mucosa is commonly used as the graft of choice in substitution urethroplasty, but donor-site morbidity remains a relevant clinical concern. Evaluating the frequency and predictors of these complications is essential for improving postoperative outcomes. This study aimed to determine the frequency, types, and predictors of donor-site complications following buccal mucosa graft harvesting.

Methods: It was a descriptive prospective study in 74 patients who had undergone buccal mucosa graft urethroplasty within a period of 12 months. Day 1-, 3- and 6-months Donor-site assessments were done. Clinical recording of complications was done. Independent t-tests, chi-square/Fisher exact tests and multivariate logistic regression were used as statistical analysis.

Results: Donor-site complications occurred in 9 patients (12.2%). Edema was noted in 6 (8.1%), difficulty in mouth opening in 3 (4.1%), bleeding in 2 (2.7%), numbness in 2 (2.7%), chewing difficulty in 2 (2.7%), and infection in 1 (1.4%). Overall mouth opening showed minimal reduction, though patients with functional limitation experienced greater declines. Larger graft area (OR 1.12, p = 0.036) and diabetes (13 patients, 17.6%; OR 3.21, p = 0.045) were significant independent predictors of complications. Donor-site closure technique—open in 41 (55.4%) and primary closure in 33 (44.6%)—was not significantly associated with morbidity (p > 0.05).

Conclusion: Buccal mucosa graft harvesting is safe and has low donor-site morbidity and most complications are mild and short-lived. One of the risk factors is the larger graft size and diabetes, which highlights the importance of careful graft planning and preoperative optimization.

Author Biographies

  • Najeeb Ullah, Sindh Institute of Urology and Transplantation Karachi Pakistan

    Department of Urology

  • Ahmad Waleed, Sindh Institute of Urology and Transplantation Karachi Pakistan

    Department of Urology

  • Syed Rafiuddin Shah, Sindh Institute of Urology and Transplantation Karachi Pakistan

    Department of Urology

  • Agha Muhammad Zubair, Sindh Institute of Urology and Transplantation Karachi Pakistan

    Department of Urology

  • Mushtaq Hussain, Sindh Institute of Urology and Transplantation Karachi Pakistan

    Department of Urology

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Published

2026-07-12

Issue

Section

Original article

How to Cite

1.
Ullah N, Waleed A, Shah SR, Zubair AM, Mustaf J, Hussain M. Donor site complications of buccal mucosa harvesting in substitution urethroplasty. Int J Pathol [Internet]. 2026 Jul. 12 [cited 2026 Jul. 12];24(2). Available from: https://mail.jpathology.com/index.php/OJS/article/view/1078